2. Signaling Pathways
  3. Neuronal Signaling
  4. Sigma Receptor
  5. Sigma Receptor Isoform
  6. Sigma Receptor Ligand

Sigma Receptor Ligand

Sigma Receptor Ligands (4):

Cat. No. Product Name Effect Purity
  • HY-90002
    4-Phenylpiperidine
    		Ligand 99.9%
    4-Phenylpiperidine is a σ receptor ligand with a Ki value of 1980 nM for guinea pig σ receptors. 4-Phenylpiperidine binds to σ receptors. 4-Phenylpiperidine is used in psychiatric disease research.
  • HY-120008
    SAS-1121
    		Ligand
    SAS-1121 is a subtype-selective sigma 2 receptor/PGRMC1 ligand with a Ki of 16.2 nM. SAS-1121 is 574-fold selective for the signma 2 receptor over the sigma 1 receptor. SAS-1121 is a tertiary amine. SAS-1121 can be studied in neurology-related research.
  • HY-119196
    Caprospinol
    		Ligand
    Caprospinol (SP-233) is a steroid compound candidate based on the structure of 22R-hydroxycholesterol. It has multiple mechanisms of neuroprotection, including binding to β-amyloid protein (Aβ(42)), interacting with the mitochondrial respiratory chain, clearing Aβ(42) monomers, and acting as a σ-1 receptor ligand. It can cross the blood-brain barrier in vivo and restore cognitive impairment, and has the potential to inhibit Alzheimer's disease.
  • HY-177345A
    SV119 hydrochloride
    		Ligand
    SV119 hydrochloride is a sigma-2 ligand with a Ki value of 5.2 nM. SV119 hydrochloride enhances the efficient transport of drugs across the plasma membrane of cancer cells. The conjugation of dm-Erastin with SV119 hydrochloride successfully overcomes the internalization barrier observed in pancreatic cancer, while preserving the inherent anti-tumor activity of Erastin (HY-15763). Additionally, SV119 hydrochloride demonstrates cytotoxic effects on triple-negative breast cancer (TNBC) cells and induces apoptosis.